Psychosomatic medicine is a branch in medicine and the science of studying the associations between psychological factors, human health, and diseases. The thought of psychosomatic medicine in Chinese medicine contains a rich content. This article, integrated with The Yellow Emperor’s Inner Classic, probes into the knowledge and research on psychosomatic-related problems so as to bring in a new angle to facilitating clinical workers to better understand the etiology and preventative principles of diseases, promoting the formation of a psychosomatic medicine system with traditional Chinese medicine characteristics.