综述

经前期综合征患者HPA轴功能失调的机制

  • 陈莅蓉 ,
  • 孟瑶 ,
  • 周仁来
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  • 南京大学社会学院心理系,南京 210023
陈莅蓉,2014 年毕业于南昌大学教育学院,获理学学士学位,随后进入南京大学社会学院心理系,攻读硕士学位。研究方向主要为社会认知神经科学,包括经前期综合征的发病机制、正念的起效机制等。
* 周仁来,rlzhou@nju.edu.cn

网络出版日期: 2024-10-18

基金资助

江苏高校哲学社会科学重点研究基地重大基金资助项目( 2015JDXM0 01); 南京大学双创示范基地重点项目(SCJD04 06)

Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Individuals with Premenstrual Syndrome and its Mechanism

  • CHEN Lirong ,
  • MENG Yao ,
  • ZHOU Renlai
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  • Psychology Department, School of Social and Behavioral Sciences, Nanjing University, Nanjing 210023, China
* ZHOU Renlai, rlzhou@nju.edu.cn

Online published: 2024-10-18

摘要

经前期综合征(premenstrual syndrome,PMS)患者下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴功能失调的机制涵盖生理、心理、社会多方面因素。文章从生理-社会-心理交互作用的角度出发,在回顾文献的基础上对PMS与HPA轴功能失调之间的关系进行分析。发现女性在经前期具有对压力敏感的生理基础,并且在社会文化的构建下,PMS患者相较于非PMS者有更强的负性月经态度,导致其经前期主观感知压力增加。而PMS患者缺乏相应的压力应对能力,所以周期性经前期压力处理失败导致PMS患者HPA轴功能的压力反应失调,即在心理性压力源下出现皮质醇分泌水平较低的现象,从而形成固定化的PMS反应模式。

本文引用格式

陈莅蓉 , 孟瑶 , 周仁来 . 经前期综合征患者HPA轴功能失调的机制[J]. 心理学通讯, 2020 , 3(4) : 237 -243 . DOI: 10.12100/j.issn.2096-5494.220005

Abstract

The mechanism of hypothalamic-pituitary-adrenal (HPA) axis dysfunction in patients with premenstrual syndrome (PMS) covers physiological, psychological, and social factors. From the perspective of physiological-social-psychological interaction, this article summarized the relationship between PMS and HPA axis dysfunction and its pathogenesis. The results found that women have a physiological basis for pressure sensitivity during the premenstrual period, and under the construction of social culture, patients with PMS have a stronger negative menstrual attitude than individuals without PMS, which leads to an increase in their subjective perceived stress during the premenstrual period. However, patients with PMS lack the corresponding stress coping ability, and failures of coping with periodic premenstrual stress lead to stress reaction dysfunction of HPA axis in patients with PMS, that is the phenomenon of low cortisol secretion under psychological stressors, thus forming an immobilized PMS reaction mode.

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